Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions

Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions

Macroautophagy, a quality control mechanism, is an evolutionarily conserved pathway of lysosomal degradation of protein aggregates, pathogens, and damaged organelles. As part of its vital homeostatic role, macroautophagy deregulation is associated with various human disorders, including neurodegener...

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Bibliographic Details
Main Authors: João Duarte Magalhães, Lígia Fão, Rita Vilaça, Sandra Morais Cardoso, Ana Cristina Rego
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Biomedicines
Subjects:
neurodegenerative disorders
autophagy
mitophagy mitochondrial dysfunction
mutant proteins
therapeutic strategies
Online Access:https://www.mdpi.com/2227-9059/9/11/1625

Internet

https://www.mdpi.com/2227-9059/9/11/1625

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