The BET degrader ZBC260 suppresses stemness and tumorigenesis and promotes differentiation in triple-negative breast cancer by disrupting inflammatory signaling

The BET degrader ZBC260 suppresses stemness and tumorigenesis and promotes differentiation in triple-negative breast cancer by disrupting inflammatory signaling

Abstract Background Breast cancer stem cells (BCSCs) are resistant to standard therapies, facilitate tumor dissemination, and contribute to relapse and progression. Super-enhancers are regulators of stemness, and BET proteins, which are critical for super-enhancer function, are a potential therapeut...

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Bibliographic Details
Main Authors: Deeksha Sharma, Cody G. Hager, Li Shang, Lam Tran, Yongyou Zhu, Aihui Ma, Brian Magnuson, Matthew W. Lesko, Max S. Wicha, Monika L. Burness
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Cancer stem cell
BET protein degrader
ZBC260
Inflammatory cytokines
Online Access:https://doi.org/10.1186/s13058-023-01715-3

Internet

https://doi.org/10.1186/s13058-023-01715-3

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