Design, Synthesis and In Vitro Evaluation of Spirooxindole-Based Phenylsulfonyl Moiety as a Candidate Anti-SAR-CoV-2 and MERS-CoV-2 with the Implementation of Combination Studies

Design, Synthesis and In Vitro Evaluation of Spirooxindole-Based Phenylsulfonyl Moiety as a Candidate Anti-SAR-CoV-2 and MERS-CoV-2 with the Implementation of Combination Studies

The search for an effective anti-viral to inhibit COVID-19 is a challenge for the specialized scientific research community. This work investigated the anti-coronavirus activity for spirooxindole-based phenylsulfone cycloadducts in a single and combination protocols. The newly designed anti-SARS-CoV...

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Bibliographic Details
Main Authors: Assem Barakat, Ahmed Mostafa, M. Ali, Abdullah Mohammed Al-Majid, Luis R. Domingo, Omnia Kutkat, Yassmin Moatasim, Komal Zia, Zaheer Ul-Haq, Yaseen A. M. M. Elshaier
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
spirooxindole
SARS-CoV-2
drug combination protocol
molecular dynamic simulation (MDS)
ADMET
Online Access:https://www.mdpi.com/1422-0067/23/19/11861

Internet

https://www.mdpi.com/1422-0067/23/19/11861

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