CHRFAM7A: A human specific fusion gene, accounts for the translational gap for cholinergic strategies in Alzheimer's disease

Background: Cholinergic neuronal loss is one of the hallmarks of AD related neurodegeneration; however, preclinical promise of α7 nAChR drugs failed to translate into humans. CHRFAM7A, a uniquely human fusion gene, is a negative regulator of α7 nAChR and was unaccounted for in preclinical models. Me...

Full description

Bibliographic Details
Main Authors: Kinga Szigeti, Ivanna Ihnatovych, Barbara Birkaya, Ziqiang Chen, Aya Ouf, Dinesh C. Indurthi, Jonathan E. Bard, Julien Kann, Alexandrea Adams, Lee Chaves, Norbert Sule, Joan S. Reisch, Valory Pavlik, Ralph H.B. Benedict, Anthony Auerbach, Gregory Wilding
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:EBioMedicine
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642030267X