Inhibition of MMP-2 and MMP-9 attenuates surgery-induced cognitive impairment in aged mice

Inhibition of MMP-2 and MMP-9 attenuates surgery-induced cognitive impairment in aged mice

Background: The inhibition of matrix metalloproteinases (MMPs) has shown potential in the treatment of various neurodegenerative diseases, and perioperative neurocognitive disorders (PND) is accompanied by the increased expression of MMP-2 and MMP-9 in the hippocampus. However, the effect of inhibit...

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Bibliographic Details
Main Authors: Yiqin Ji, Wanbo Huang, Yijun Chen, Xincai Zhang, Fan Wu, Wan Tang, Zihui Lu, Changshun Huang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Brain Research Bulletin
Subjects:
Perioperative neurocognitive disorder
Matrix metalloproteases
Blood-brain barrier
Neuroinflammation
Aged mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923023002356

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http://www.sciencedirect.com/science/article/pii/S0361923023002356

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