Activated Platelets Autocrine 5-Hydroxytryptophan Aggravates Sepsis-Induced Acute Lung Injury by Promoting Neutrophils Extracellular Traps Formation

Activated Platelets Autocrine 5-Hydroxytryptophan Aggravates Sepsis-Induced Acute Lung Injury by Promoting Neutrophils Extracellular Traps Formation

Excessive neutrophil extracellular trap (NET) formation is an important contributor to sepsis-induced acute lung injury (ALI). Recent reports indicate that platelets can induce neutrophil extracellular trap formation. However, the specific mechanism remains unclear. Tph1 gene, which encodes the rate...

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Bibliographic Details
Main Authors: Yumeng Huang, Qian Ji, Yanyan Zhu, Shengqiao Fu, Shuangwei Chen, Liangmei Chu, Yongfei Ren, Yue Wang, Xuan Lei, Jia Gu, Ningzheng Tai, Dadong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
sepsis
acute lung injury (ALI)
5-hydroxytryptophan (5-HT)
neutrophil extracellular traps (NETs)
neutrophil
platelet
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.777989/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.777989/full

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