Clostridium scindens secretome suppresses virulence gene expression of Clostridioides difficile in a bile acid-independent manner

Clostridium scindens secretome suppresses virulence gene expression of Clostridioides difficile in a bile acid-independent manner

ABSTRACT Clostridioides difficile infection (CDI) is a major health concern and one of the leading causes of hospital-acquired diarrhea in many countries. C. difficile infection is challenging to treat as C. difficile is resistant to multiple antibiotics. Alternative solutions are needed as conventi...

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Bibliographic Details
Main Authors: Carmen Saenz, Qing Fang, Thiyagarajan Gnanasekaran, Samuel Addison Jack Trammell, Jesse Arnold Buijink, Paola Pisano, Michael Wierer, Frédéric Moens, Bettina Lengger, Asker Brejnrod, Manimozhiyan Arumugam
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
Clostridioides difficile infection
Clostridium scindens
bile acids
secretome
Human Intestinal Microbial Ecosystem
gut microbiome
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03933-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03933-22

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