The cell cycle inhibitor P21 promotes the development of pulmonary fibrosis by suppressing lung alveolar regeneration

The cell cycle inhibitor P21 promotes the development of pulmonary fibrosis by suppressing lung alveolar regeneration

The cell cycle inhibitor P21 has been implicated in cell senescence and plays an important role in the injury–repair process following lung injury. Pulmonary fibrosis (PF) is a fibrotic lung disorder characterized by cell senescence in lung alveolar epithelial cells. In this study, we report that P2...

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Bibliographic Details
Main Authors: Xiaoxi Lv, Chang Liu, Shanshan Liu, Yunxuan Li, Wanyu Wang, Ke Li, Fang Hua, Bing Cui, Xiaowei Zhang, Jiaojiao Yu, Jinmei Yu, ZhuoWei Hu
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
P21
Cell senescence
Alveolar epithelial type 2 cells
Pulmonary fibrosis
Alveolar regeneration
Bleomycin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521002641

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http://www.sciencedirect.com/science/article/pii/S2211383521002641

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