Lessons Learned in Protein Precipitation Using a Membrane Emulsification Technique to Produce Reversible and Uniform Microbeads

Lessons Learned in Protein Precipitation Using a Membrane Emulsification Technique to Produce Reversible and Uniform Microbeads

The effects of the manufacturing process and the regeneration of Shirasu porous glass (SPG) membranes were investigated on the reproducibility of protein precipitants, termed protein microbeads. Intravenous immunoglobulin (IVIG) was selected as a model protein to produce its microbeads in seven diff...

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Bibliographic Details
Main Authors: Sang-Koo Park, Ga Yeon Noh, Hyun Woo Yu, Eun Chae Lee, Junoh Jeong, Young-Min Park, Hyo-Kyung Han, Seong Hoon Jeong, Nam Ah Kim
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceutics
Subjects:
membrane emulsification
protein stability
protein aggregation
SPG membrane
trehalose
intravenous IgG (IVIG)
Online Access:https://www.mdpi.com/1999-4923/13/10/1738

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https://www.mdpi.com/1999-4923/13/10/1738

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