Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia[S]

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia[S]

In an attempt to understand the applicability of various animal models to dyslipidemia in humans and to identify improved preclinical models for target discovery and validation for dyslipidemia, we measured comprehensive plasma lipid profiles in 24 models. These included five mouse strains, six othe...

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Bibliographic Details
Main Authors: Wu Yin, Ester Carballo-Jane, David G. McLaren, Vivienne H. Mendoza, Karen Gagen, Neil S. Geoghagen, Lesley Ann McNamara, Judith N. Gorski, George J. Eiermann, Aleksandr Petrov, Michael Wolff, Xinchun Tong, Larissa C. Wilsie, Taro E. Akiyama, Jing Chen, Anil Thankappan, Jiyan Xue, Xiaoli Ping, Genevieve Andrews, L. Alexandra Wickham, Cesaire L. Gai, Tu Trinh, Alison A. Kulick, Marcie J. Donnelly, Gregory O. Voronin, Ray Rosa, Anne-Marie Cumiskey, Kavitha Bekkari, Lyndon J. Mitnaul, Oscar Puig, Fabian Chen, Richard Raubertas, Peggy H. Wong, Barbara C. Hansen, Ken S. Koblan, Thomas P. Roddy, Brian K Hubbard, Alison M. Strack
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Lipid Research
Subjects:
lipidomic
statins
preclinical animal models
cholesterol
low-density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520407990

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http://www.sciencedirect.com/science/article/pii/S0022227520407990

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