FcRγ controls the fas-dependent regulatory function of lymphoproliferative double negative T cells.

FcRγ controls the fas-dependent regulatory function of lymphoproliferative double negative T cells.

Patients with autoimmune lymphoproliferative syndrome (ALPS) and lymphoproliferation (LPR) mice are deficient in Fas, and accumulate large numbers of αβ-TCR(+), CD4(-), CD8(-) double negative (DN) T cells. The function of these DN T cells remains largely unknown. The common γ subunit of the activati...

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Bibliographic Details
Main Authors: Stephen C Juvet, Christopher W Thomson, Edward Y Kim, Mei Han, Li Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3675138?pdf=render

Internet

http://europepmc.org/articles/PMC3675138?pdf=render

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