Symmetrical Heterocyclic Cage Skeleton: Synthesis, Urease Inhibition Activity, Kinetic Mechanistic Insight, and Molecular Docking Analyses

Symmetrical Heterocyclic Cage Skeleton: Synthesis, Urease Inhibition Activity, Kinetic Mechanistic Insight, and Molecular Docking Analyses

The present study focuses on the design and synthesis of a cage-like organic skeleton containing two triazole rings jointed via imine linkage. These molecules can act as urease inhibitors. The in-vitro urease inhibition screening results showed that the combination of the two triazole skeleton in th...

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Bibliographic Details
Main Authors: Muhammad Hanif, Fariha Kanwal, Muhammad Rafiq, Mubashir Hassan, Muhammad Mustaqeem, Sung-Yum Seo, Yunlong Zhang, Changrui Lu, Ting Chen, Muhammad Saleem
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Molecules
Subjects:
heterocyclic cage
urease inhibition
metal complexes
lineweaver–burk plot
molecular docking
Online Access:http://www.mdpi.com/1420-3049/24/2/312

Internet

http://www.mdpi.com/1420-3049/24/2/312

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