Oxidative stress induced by NOX2 contributes to neuropathic pain via plasma membrane translocation of PKCε in rat dorsal root ganglion neurons

Oxidative stress induced by NOX2 contributes to neuropathic pain via plasma membrane translocation of PKCε in rat dorsal root ganglion neurons

Abstract Background Nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2)-induced oxidative stress, including the production of reactive oxygen species (ROS) and hydrogen peroxide, plays a pivotal role in neuropathic pain. Although the activation and plasma membrane translocation of protein k...

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Bibliographic Details
Main Authors: Jing Xu, Shinan Wu, Junfei Wang, Jianmei Wang, Yi Yan, Mengye Zhu, Daying Zhang, Changyu Jiang, Tao Liu
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Neuroinflammation
Subjects:
Neuropathic pain
Dorsal root ganglion
NADPH oxidase 2
Reactive oxygen species
Protein kinase Cε
Online Access:https://doi.org/10.1186/s12974-021-02155-6

Internet

https://doi.org/10.1186/s12974-021-02155-6

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