Calcimimetic R-568 and its enantiomer S-568 increase nitric oxide release in human endothelial cells.

Calcimimetic R-568 and its enantiomer S-568 increase nitric oxide release in human endothelial cells.

Calcimimetics, such as R-568, are thought to activate G protein-linked Ca(2+)-sensing receptor (CaSR) by allosterically increasing the affinity of the receptor for Ca(2+) allowing for efficient control of uremic hyperparathyroidism. Several recent studies suggest they possess additional vascular act...

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Bibliographic Details
Main Authors: Mario Bonomini, Annalisa Giardinelli, Caterina Morabito, Sara Di Silvestre, Moreno Di Cesare, Natalia Di Pietro, Vittorio Sirolli, Gloria Formoso, Luigi Amoroso, Maria Addolorata Mariggiò, Assunta Pandolfi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3266284?pdf=render

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http://europepmc.org/articles/PMC3266284?pdf=render

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