Calcimimetic R-568 and its enantiomer S-568 increase nitric oxide release in human endothelial cells.
Calcimimetics, such as R-568, are thought to activate G protein-linked Ca(2+)-sensing receptor (CaSR) by allosterically increasing the affinity of the receptor for Ca(2+) allowing for efficient control of uremic hyperparathyroidism. Several recent studies suggest they possess additional vascular act...
Main Authors: | Mario Bonomini, Annalisa Giardinelli, Caterina Morabito, Sara Di Silvestre, Moreno Di Cesare, Natalia Di Pietro, Vittorio Sirolli, Gloria Formoso, Luigi Amoroso, Maria Addolorata Mariggiò, Assunta Pandolfi |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3266284?pdf=render |
Similar Items
-
New Trends in Pathology: From Cell Morphology to Molecular Medicine
by: Maria Addolorata Bonifacio, et al.
Published: (2023-07-01) -
15.568A Management Information Systems, Spring 2003
by: Gibson, Cyrus F.
Published: (2003) -
Correction to Lancet Glob Health 2016; 4: e568–78
Published: (2016-11-01) -
1 pint (568 ml) multi-trip glass bottles for pasteurized milk
by: 8096 British Standards Institution -
مدينة وبذة Huete الأندلسية (93-568هـ / 711-1172م)
by: Jassim Al-Darwish, et al.
Published: (2021-07-01)