Temporal genome-wide fitness analysis of Mycobacterium marinum during infection reveals the genetic requirement for virulence and survival in amoebae and microglial cells

Temporal genome-wide fitness analysis of Mycobacterium marinum during infection reveals the genetic requirement for virulence and survival in amoebae and microglial cells

ABSTRACTTuberculosis remains the most pervasive infectious disease and the recent emergence of drug-resistant strains emphasizes the need for more efficient drug treatments. A key feature of pathogenesis, conserved between the human pathogen Mycobacterium tuberculosis and the model pathogen Mycobact...

Full description

Bibliographic Details
Main Authors: Louise H. Lefrançois, Jahn Nitschke, Huihai Wu, Gaël Panis, Julien Prados, Rachel E. Butler, Tom A. Mendum, Nabil Hanna, Graham R. Stewart, Thierry Soldati
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mSystems
Subjects:
Mycobacterium marinum
phenotypic profiling
Dictyostelium discoideum
BV2 microglial cells
essentiality
Tn-Seq
Online Access:https://journals.asm.org/doi/10.1128/msystems.01326-23

Internet

https://journals.asm.org/doi/10.1128/msystems.01326-23

Similar Items