PD-L1 and HIF-2α Upregulation in Head and Neck Paragangliomas after Embolization

PD-L1 and HIF-2α Upregulation in Head and Neck Paragangliomas after Embolization

Hypoxia activates pathways associated with tumor progression, metastatic spread, and alterations in the immune microenvironment leading to an immunosuppressive phenotype. In particular, the upregulation of PD-L1, a target for therapy with checkpoint inhibitors, is well-studied in several tumors. How...

Full description

Bibliographic Details
Main Authors: Alessa Fischer, Umberto Maccio, Katharina Wang, Juliane Friemel, Martina A. Broglie Daeppen, Diana Vetter, Kuno Lehmann, Astrid Reul, Mercedes Robledo, Constanze Hantel, Nicole Bechmann, Karel Pacak, Kathrin Zitzmann, Christoph J. Auernhammer, Ashley B. Grossman, Felix Beuschlein, Svenja Nölting
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cancers
Subjects:
Paraganglioma
HNPGL
embolization
hypoxia
PD-L1
HIF2α
Online Access:https://www.mdpi.com/2072-6694/15/21/5199

Internet

https://www.mdpi.com/2072-6694/15/21/5199

Similar Items