Medroxyprogesterone promotes neuronal survival after cerebral ischemic stroke by inhibiting PARthanatos

Medroxyprogesterone promotes neuronal survival after cerebral ischemic stroke by inhibiting PARthanatos

IntroductionCerebral ischemic stroke (CIS) is caused by the interruption of cerebral blood circulation due to thrombosis or embolism and is the second-leading cause of mortality worldwide. The neuronal death and motor dysfunction resulting from CIS are primarily attributed to the induction of PARtha...

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Bibliographic Details
Main Authors: Chang-Ling Yue, Yan-Xia Ding, Meng Chen, Yu-Xin Shen, Ao-Meng Hu, Hai Huang, Zhao-Huan Zhang, Ying-Xin Zhou, Xiao-Hui Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
medroxyprogesterone
PARthanatos
apoptosis-inducing factor
extracellular signal-regulated kinase
cerebral ischemic stroke
approved drug library
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1487436/full

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https://www.frontiersin.org/articles/10.3389/fphar.2025.1487436/full

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