4-Aryl-N-phenylpyrimidin-2-amines targeting EGFR-tyrosine kinase attenuated EGFR-expressing cell lines

4-Aryl-N-phenylpyrimidin-2-amines targeting EGFR-tyrosine kinase attenuated EGFR-expressing cell lines

Target therapies have been widely developed to combat various diseases and cancer. Epidermal Growth Factor Receptor is still a currently therapeutic target for solid tumor. Aberration of EGFR activity or expression reflect disease progression and poor prognosis. Recently, several newly synthesized 4...

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Bibliographic Details
Main Authors: Lueacha Tabtimmai, Prapasri Supakun, Borvornvat Toviwek, Nattanan Jiwacharoenchai, Duangnapa Kiriwan, Thitinan Aiebchun, M. Paul Gleeson, Kiattawee Choowongkomon
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Epidermal growth factor receptor (EGFR)
Tyrosine kinase inhibitors (TKIs)
4-Aryl-N-Phenylpyrimidin-2-amine compounds
Cancer hallmarks
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417422000346

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http://www.sciencedirect.com/science/article/pii/S2772417422000346

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