EN1 promotes lung metastasis of salivary adenoid cystic carcinoma by regulating the PI3K-AKT pathway and epithelial-mesenchymal transition

EN1 promotes lung metastasis of salivary adenoid cystic carcinoma by regulating the PI3K-AKT pathway and epithelial-mesenchymal transition

Abstract Background Engrailed homeobox 1 (EN1) is a candidate oncogene that is epigenetically modified in salivary adenoid cystic carcinoma (SACC). We investigated the expression of EN1 in SACC tissues and cells, EN1 promoter methylation, and the role of EN1 in tumour progression in SACC. Methods Th...

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Bibliographic Details
Main Authors: Yajuan Cui, Ye Zhang, Yuping Liu, Zheng Zhou, Lijing Zhu, Chuan-Xiang Zhou
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cancer Cell International
Subjects:
Salivary adenoid cystic carcinoma
Engrailed 1
Metastasis
Methylation
Epithelial-mesenchymal transition
Online Access:https://doi.org/10.1186/s12935-024-03230-7

Internet

https://doi.org/10.1186/s12935-024-03230-7

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