Betaine supplementation alleviates corticosterone-induced hepatic cholesterol accumulation through epigenetic modulation of HMGCR and CYP7A1 genes in laying hens

Betaine supplementation alleviates corticosterone-induced hepatic cholesterol accumulation through epigenetic modulation of HMGCR and CYP7A1 genes in laying hens

ABSTRACT: Excessive corticosterone (CORT) exposure could cause hepatic cholesterol accumulation in chickens and maternal betaine supplementation could decrease hepatic cholesterol deposition through epigenetic modifications in offspring chickens. Nevertheless, it remains uncertain whether providing...

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Bibliographic Details
Main Authors: Yulin Wu, Mengwei Zhang, Fanchi Meng, Kunpeng Ren, Ding Li, Xugang Luo, Yun Hu
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Poultry Science
Subjects:
laying hen
betaine
cholesterol metabolism
corticosterone
DNA methylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0032579124000142

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http://www.sciencedirect.com/science/article/pii/S0032579124000142

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