Calcium Microdomain Formation at the Perisynaptic Cradle Due to NCX Reversal: A Computational Study

Calcium Microdomain Formation at the Perisynaptic Cradle Due to NCX Reversal: A Computational Study

It has recently been proposed using a multi-compartmental mathematical model that negatively fixed charged membrane-associated sites constrain the flow of cations in perisynaptic astroglial processes. This restricted movement of ions between the perisynaptic cradle (PsC), principal astroglial proces...

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Bibliographic Details
Main Authors: John Joseph Wade, Kevin Breslin, KongFatt Wong-Lin, Jim Harkin, Bronac Flanagan, Harm Van Zalinge, Steve Hall, Mark Dallas, Angela Bithell, Alexei Verkhratsky, Liam McDaid
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
perisynaptic cradle
calcium microdomains
astrocytic process
Na+/Ca2+ exchange
compartment model
glutamate transport
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00185/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00185/full

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