Adapalene and Doxorubicin Synergistically Promote Apoptosis of TNBC Cells by Hyperactivation of the ERK1/2 Pathway Through ROS Induction

Adapalene and Doxorubicin Synergistically Promote Apoptosis of TNBC Cells by Hyperactivation of the ERK1/2 Pathway Through ROS Induction

Doxorubicin is a commonly used chemotherapeutic agent to treat several malignancies, including aggressive tumors like triple-negative breast cancer. It has a limited therapeutic index owing to its extreme toxicity and the emergence of drug resistance. As a result, there is a pressing need to find in...

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Bibliographic Details
Main Authors: Umar Mehraj, Irfan Ahmad Mir, Mahboob ul Hussain, Mustfa Alkhanani, Nissar Ahmad Wani, Manzoor Ahmad Mir
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
breast cancer
TNBC
doxorubicin
adapalene
Chou-Talalay
combination therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.938052/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.938052/full

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