A functional role for Serum Amyloid A in the molecular regulation of autophagy in breast cancer

It has been established that the acute phase protein, Serum amyloid A (SAA), which is usually synthesized by the liver, is also synthesized by cancer cells and cancer-associated cells in the tumor microenvironment. SAA also activates modulators of autophagy, such as the PI3K/Akt and MAPK signaling p...

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Bibliographic Details
Main Authors: Manisha du Plessis, Tanja Andrea Davis, Daniel Wilhelm Olivier, Willem Johan Simon de Villiers, Anna-Mart Engelbrecht
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
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Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1000925/full