Adhesion molecules and cerebral microvascular hemodynamic abnormalities in sickle cell disease

Cerebrovascular abnormalities are a common feature of sickle cell disease that may be associated with risk of vaso-occlusive pain crises, microinfarcts, and cognitive impairment. An activated endothelium and adhesion factors, VCAM-1 and P-selectin, are implicated in sickle cell vasculopathy, includi...

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Bibliographic Details
Main Authors: Noor Mary Abi Rached, Oluwabukola T. Gbotosho, David R. Archer, Jayre A. Jones, Morgan S. Sterling, Hyacinth I. Hyacinth
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Neurology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.976063/full