<i>MLH1</i> Methylation Testing as an Integral Component of Universal Endometrial Cancer Screening—A Critical Appraisal

<i>MLH1</i> Methylation Testing as an Integral Component of Universal Endometrial Cancer Screening—A Critical Appraisal

MLH1/PMS2 loss due to <i>MLH1</i> promoter hypermethylation (<i>MLH1</i>-PHM) is the most common cause of mismatch repair (MMR) deficiency in endometrial cancer (EC). This study aimed to determine the proportion of <i>MLH1</i>-deficient EC with PHM, assess the imp...

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Bibliographic Details
Main Authors: Anna Plotkin, Ekaterina Olkhov-Mitsel, Sharon Nofech-Mozes
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cancers
Subjects:
endometrial cancer
lynch syndrome
mismatch repair deficiency testing
<i>MLH1</i> promoter methylation analysis
gynecologic pathology
immunohistochemistry
Online Access:https://www.mdpi.com/2072-6694/15/21/5188

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https://www.mdpi.com/2072-6694/15/21/5188

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