Crocin mitigates atherosclerotic progression in LDLR knockout mice by hepatic oxidative stress and inflammatory reaction reduction, and intestinal barrier improvement and gut microbiota modulation

Crocin has a protective effect on neurodegenerative disease, but whether crocin can prevent atherosclerosis remains unclear. The present study aimed to explore the possible anti-atherosclerotic mechanism of crocin in LDLR-/- mice. Mice were fed an atherogenic high-fat/cholesterol diet and concomitan...

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Bibliographic Details
Main Authors: Shufen Han, Ruijuan Song, Yifei Cao, Xiao Yan, Hui Gao, Fuzhi Lian
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Journal of Functional Foods
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464622002912