Development of a Bispecific IgG1 Antibody Targeting BCMA and PDL1

Development of a Bispecific IgG1 Antibody Targeting BCMA and PDL1

We designed, produced, and purified a novel IgG1-like, bispecific antibody (bsAb) directed against B-cell maturation antigen (BCMA), expressed by multiple myeloma (MM) cells, and an immune checkpoint inhibitor (ICI), PDL1, expressed in the MM microenvironment. The BCMA×PDL1 bsAb was fully characteri...

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Bibliographic Details
Main Authors: Irene Cattaneo, Sylvie Choblet, Rut Valgardsdottir, Muriel Roth, Annamaria Massafra, Marten Beeg, Marco Gobbi, Martine Duonor-Cerutti, Josée Golay
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Antibodies
Subjects:
bispecific antibody
multiple myeloma
BCMA
checkpoint inhibitor
PDL1
Online Access:https://www.mdpi.com/2073-4468/13/1/15

Internet

https://www.mdpi.com/2073-4468/13/1/15

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