A nuclear-based quality control pathway for non-imported mitochondrial proteins

A nuclear-based quality control pathway for non-imported mitochondrial proteins

Mitochondrial import deficiency causes cellular toxicity due to the accumulation of non-imported mitochondrial precursor proteins, termed mitoprotein-induced stress. Despite the burden mis-localized mitochondrial precursors place on cells, our understanding of the systems that dispose of these prote...

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Bibliographic Details
Main Authors: Viplendra PS Shakya, William A Barbeau, Tianyao Xiao, Christina S Knutson, Max H Schuler, Adam L Hughes
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
mitochondria
nucleus
protein import
protein quality control
proteasome
Online Access:https://elifesciences.org/articles/61230

Internet

https://elifesciences.org/articles/61230

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