Phenformin suppresses angiogenesis through the regulation of exosomal microRNA-1246 and microRNA-205 levels derived from oral squamous cell carcinoma cells

Exosomes secreted by cancer cells are important components in the tumor microenvironment, enabling cancer cells to communicate with each other and with noncancerous cells to play important roles in tumor progression and metastasis. Phenformin, a biguanide antidiabetic drug, has been reported to have...

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Bibliographic Details
Main Authors: Dexuan Zhuang, Shuangshuang Wang, Guanyi Liu, Panpan Liu, Huiting Deng, Jianfeng Sun, Chang Liu, Xue Leng, Qun Zhang, Fuxiang Bai, Jun Mi, Xunwei Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.943477/full