Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19

Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19

Respiratory failure in COVID-19 is characterized by widespread disruption of the lung’s alveolar gas exchange interface. To elucidate determinants of alveolar lung damage, we performed epithelial and immune cell profiling in lungs from 24 COVID-19 autopsies and 43 uninfected organ donors ages 18–92...

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Bibliographic Details
Main Authors: Michael Chait, Mine M. Yilmaz, Shanila Shakil, Amy W. Ku, Pranay Dogra, Thomas J. Connors, Peter A. Szabo, Joshua I. Gray, Steven B. Wells, Masaru Kubota, Rei Matsumoto, Maya M.L. Poon, Mark E. Snyder, Matthew R. Baldwin, Peter A. Sims, Anjali Saqi, Donna L. Farber, Stuart P. Weisberg
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-06-01
Series:JCI Insight
Subjects:
Aging
COVID-19
Online Access:https://doi.org/10.1172/jci.insight.157608

Internet

https://doi.org/10.1172/jci.insight.157608

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