Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival

Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival

Ischemia-reperfusion injury (IRI) amplifies T cell alloimmune responses after transplantation with thrombin playing a key pro-inflammatory role. To explore the influence of thrombin on regulatory T cell recruitment and efficacy we used a well-established model of IRI in the native murine kidney. Adm...

Full description

Bibliographic Details
Main Authors: Qi Peng, Anna Nowocin, Kulachelvy Ratnasothy, Richard A. Smith, Lesley A. Smyth, Robert I. Lechler, Anthony Dorling, Giovanna Lombardi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
murine heart transplantation
murine renal ischemia/reperfusion injury
coagulation cascade
thrombin
membrane-localizing thrombin inhibitor PTL060
regulatory T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.980462/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.980462/full

Similar Items