The hypoxia response pathway promotes PEP carboxykinase and gluconeogenesis in C. elegans

The hypoxia response pathway promotes PEP carboxykinase and gluconeogenesis in C. elegans

Abstract Actively dividing cells, including some cancers, rely on aerobic glycolysis rather than oxidative phosphorylation to generate energy, a phenomenon termed the Warburg effect. Constitutive activation of the Hypoxia Inducible Factor (HIF-1), a transcription factor known for mediating an adapti...

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Bibliographic Details
Main Authors: Mehul Vora, Stephanie M. Pyonteck, Tatiana Popovitchenko, Tarmie L. Matlack, Aparna Prashar, Nanci S. Kane, John Favate, Premal Shah, Christopher Rongo
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33849-x

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https://doi.org/10.1038/s41467-022-33849-x

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