A complex genomic locus drives mtDNA replicase POLG expression to its disease‐related nervous system regions
Abstract DNA polymerase gamma (POLG), the mtDNA replicase, is a common cause of mitochondrial neurodegeneration. Why POLG defects especially cause central nervous system (CNS) diseases is unknown. We discovered a complex genomic regulatory locus for POLG, containing three functional CNS‐specific enh...
| Main Authors: | , , , , , , , , |
|---|---|
| 格式: | 文件 |
| 语言: | English |
| 出版: |
Springer Nature
2017-11-01
|
| 丛编: | EMBO Molecular Medicine |
| 主题: | |
| 在线阅读: | https://doi.org/10.15252/emmm.201707993 |