Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration

Abstract Epigenome alteration in chondrocytes correlates with osteoarthritis (OA) development. H3K27me3 demethylase UTX regulates tissue homeostasis and deterioration, while its role was not yet studied in articulating joint tissue in situ. We now uncovered that increased UTX and H3K27me3 expression...

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Bibliographic Details
Main Authors: Wei-Shiung Lian, Re-Wen Wu, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Chun-Ping Yu, Holger Jahr, Feng-Sheng Wang
Format: Article
Language:English
Published: Nature Publishing Group 2022-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04985-5