Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences

Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences

Preeclampsia (PE) is a high-prevalence pregnancy disease characterized by placental insufficiency, gestational hypertension, and proteinuria. Overexpression of the A isoform of the STOX1 transcription factor (STOX1A) recapitulates PE in mice, and STOX1A overexpressing trophoblasts recapitulate PE pa...

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Bibliographic Details
Main Authors: Laurent Chatre, Aurélien Ducat, Frank T. Spradley, Ana C. Palei, Christiane Chéreau, Betty Couderc, Kamryn C. Thomas, Anna R. Wilson, Lorena M. Amaral, Irène Gaillard, Céline Méhats, Isabelle Lagoutte, Sébastien Jacques, Francisco Miralles, Frédéric Batteux, Joey P. Granger, Miria Ricchetti, Daniel Vaiman
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Redox Biology
Subjects:
STOX1
iNOS
Malate
Nitroso-redox balance
Mitochondria
Tetrahydrobiopterin
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722001781

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http://www.sciencedirect.com/science/article/pii/S2213231722001781

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