Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences
Preeclampsia (PE) is a high-prevalence pregnancy disease characterized by placental insufficiency, gestational hypertension, and proteinuria. Overexpression of the A isoform of the STOX1 transcription factor (STOX1A) recapitulates PE in mice, and STOX1A overexpressing trophoblasts recapitulate PE pa...
Main Authors: | Laurent Chatre, Aurélien Ducat, Frank T. Spradley, Ana C. Palei, Christiane Chéreau, Betty Couderc, Kamryn C. Thomas, Anna R. Wilson, Lorena M. Amaral, Irène Gaillard, Céline Méhats, Isabelle Lagoutte, Sébastien Jacques, Francisco Miralles, Frédéric Batteux, Joey P. Granger, Miria Ricchetti, Daniel Vaiman |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2022-09-01
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Series: | Redox Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231722001781 |
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