Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos

Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos

Abstract Somatic cell nuclear transfer (SCNT) can be used to reprogram differentiated somatic cells to a totipotent state but has poor efficiency in supporting full-term development. H3K9me3 is considered to be an epigenetic barrier to zygotic genomic activation in 2-cell SCNT embryos. However, the...

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Bibliographic Details
Main Authors: Ruimin Xu, Qianshu Zhu, Yuyan Zhao, Mo Chen, Lingyue Yang, Shijun Shen, Guang Yang, Zhifei Shi, Xiaolei Zhang, Qi Shi, Xiaochen Kou, Yanhong Zhao, Hong Wang, Cizhong Jiang, Chong Li, Shaorong Gao, Xiaoyu Liu
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40496-3

Internet

https://doi.org/10.1038/s41467-023-40496-3

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