Using combined single-cell gene expression, TCR sequencing and cell surface protein barcoding to characterize and track CD4+ T cell clones from murine tissues

Using combined single-cell gene expression, TCR sequencing and cell surface protein barcoding to characterize and track CD4+ T cell clones from murine tissues

Single-cell gene expression analysis using sequencing (scRNA-seq) has gained increased attention in the past decades for studying cellular transcriptional programs and their heterogeneity in an unbiased manner, and novel protocols allow the simultaneous measurement of gene expression, T-cell recepto...

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Bibliographic Details
Main Authors: Annekathrin Silvia Nedwed, Sara Salome Helbich, Kathrin Luise Braband, Michael Volkmar, Michael Delacher, Federico Marini
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
scRNA seq
scTCR seq
TCR (T-cell receptor)
CD4 T cell
tissue CD4 T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1241283/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1241283/full

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