Candidate gene family-based and case-control studies of susceptibility to high Schistosoma mansoni worm burden in African children: a protocol [version 2; peer review: 2 approved]

Candidate gene family-based and case-control studies of susceptibility to high Schistosoma mansoni worm burden in African children: a protocol [version 2; peer review: 2 approved]

Background: Approximately 25% of the risk of Schistosoma mansoni is associated with host genetic variation. We will test 24 candidate genes, mainly in the Th2 and Th17 pathways, for association with S. mansoni infection intensity in four African countries, using family based and case-control approac...

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Bibliographic Details
Main Authors: Sokouri A. Edwige, Oscar A. Nyangiri, Estelle Mewamba, P.L.A.M Corstjens, Mathurin Koffi, Joyce Namulondo, G.J. van Dam, Gustave Simo, M. Casacuberta-Partal, Alison Elliott, Julius Mulindwa, Dieudonne Mumba, Harry Noyes, Kévin Karume, Bruno Bucheton, Enock Matovu, Jacent Nassuuna
Format: Article
Language:English
Published: F1000 Research Ltd 2021-12-01
Series:AAS Open Research
Subjects:
S. mansoni
infection intensity
family based linkage
haplotypes
candidate genes
eng
Online Access:https://aasopenresearch.org/articles/4-36/v2

Internet

https://aasopenresearch.org/articles/4-36/v2

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