Phloretin-induced suppression of oxidative and nitrosative stress attenuates doxorubicin-induced cardiotoxicity in rats

Phloretin-induced suppression of oxidative and nitrosative stress attenuates doxorubicin-induced cardiotoxicity in rats

Objective: To compare the cardioprotective efficacy of equimolar doses (50 mM/kg, p.o.) of phloretin and genistein against doxorubicin-induced cardiotoxicity in rats. Methods: Cardiotoxicity was induced in rats by intraperitoneal injection of 6 mg/kg doxorubicin on alternative days till the cumulati...

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Bibliographic Details
Main Authors: Shivani S Wagh, Kalpesh R Patil, Umesh B Mahajan, Pradnya D Bagal, Avinash R Wadkar, Basavraj Bommanhalli, Prabhakar R Patil, Sameer N Goyal, Shreesh Ojha, Chandragouda R Patil
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Asian Pacific Journal of Tropical Biomedicine
Subjects:
cardiotoxicity; chemoprevention; doxorubicin; genistein; phloretin; phytoestrogens; cardiac injury; hemodynamic changes
Online Access:http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=3;spage=124;epage=131;aulast=Wagh

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http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=3;spage=124;epage=131;aulast=Wagh

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