Sex differences in VTA GABA transmission and plasticity during opioid withdrawal

Abstract The effectiveness of current treatments for opioid use disorder (OUD) varies by sex. Our understanding of the neurobiological mechanisms mediating negative states during withdrawal is lacking, particularly with regard to sex differences. Based on preclinical research in male subjects, opioi...

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Bibliographic Details
Main Authors: Daniel J. Kalamarides, Aditi Singh, Shannon L. Wolfman, John A. Dani
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35673-9