A Designed α‐GalCer Analog Promotes Considerable Th1 Cytokine Response by Activating the CD1d‐iNKT Axis and CD11b‐Positive Monocytes/Macrophages

A Designed α‐GalCer Analog Promotes Considerable Th1 Cytokine Response by Activating the CD1d‐iNKT Axis and CD11b‐Positive Monocytes/Macrophages

Abstract Selective helper T cell 1 (Th1) priming agonists are a promising area of investigation for immunotherapeutic treatment of various diseases. α‐galactosylceramide (α‐GalCer, KRN7000), a well‐studied Th1‐polarizer, simultaneously induces helper T cell 2 (Th2)‐type responses, which is a major d...

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Bibliographic Details
Main Authors: Juan Ma, Peng He, Chuanfang Zhao, Quanzhong Ren, Zheng Dong, Jiahuang Qiu, Yang Jing, Sijin Liu, Yuguo Du
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Advanced Science
Subjects:
antitumor activity
CD11b monocytes
CD1d
Th1‐biased immune responses
α‐GalCer analogs
Online Access:https://doi.org/10.1002/advs.202000609

Internet

https://doi.org/10.1002/advs.202000609

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