Restoring the Platelet miR-223 by Calpain Inhibition Alleviates the Neointimal Hyperplasia in Diabetes

Restoring the Platelet miR-223 by Calpain Inhibition Alleviates the Neointimal Hyperplasia in Diabetes

Platelet hyperactivity is the hallmark of diabetes, and platelet activation plays a crucial role in diabetic vascular complications. Recent studies have shown that upon activation, platelet-derived miRNAs are incorporated into vascular smooth muscle cells (VSMCs), regulating the phenotypic switch of...

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Bibliographic Details
Main Authors: Meiling Su, Shunyang Fan, Zhenwei Ling, Xuejiao Fan, Luoxing Xia, Yingying Liu, Shaoying Li, Yuan Zhang, Zhi Zeng, Wai Ho Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Physiology
Subjects:
diabetes mellitus
platelet
vascular smooth muscle cells
miR-223
calpain
neointimal hyperplasia
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00742/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00742/full

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