Aryl-4,5-dihydro-1<i>H</i>-pyrazole-1-carboxamide Derivatives Bearing a Sulfonamide Moiety Show Single-digit Nanomolar-to-Subnanomolar Inhibition Constants against the Tumor-associated Human Carbonic Anhydrases IX and XII

Aryl-4,5-dihydro-1<i>H</i>-pyrazole-1-carboxamide Derivatives Bearing a Sulfonamide Moiety Show Single-digit Nanomolar-to-Subnanomolar Inhibition Constants against the Tumor-associated Human Carbonic Anhydrases IX and XII

A series of new 3-phenyl-5-aryl-<i>N</i>-(4-sulfamoylphenyl)-4,5-dihydro-1<i>H</i>-pyrazole-1-carboxamide derivatives was designed here, synthesized, and studied for carbonic anhydrase (CAs, EC 4.2.1.1) inhibitory activity against the human (h) isozymes I, II, and VII (cytoso...

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Bibliographic Details
Main Authors: Priya Hargunani, Nikhil Tadge, Mariangela Ceruso, Janis Leitans, Andris Kazaks, Kaspars Tars, Paola Gratteri, Claudiu T. Supuran, Alessio Nocentini, Mrunmayee P. Toraskar
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
sulfonamide
pyrazoline
human carbonic anhydrase
inhibition
selectivity
docking
Online Access:https://www.mdpi.com/1422-0067/21/7/2621

Internet

https://www.mdpi.com/1422-0067/21/7/2621

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