Mesenchymal stromal cells ameliorate diabetes‐induced muscle atrophy through exosomes by enhancing AMPK/ULK1‐mediated autophagy

Mesenchymal stromal cells ameliorate diabetes‐induced muscle atrophy through exosomes by enhancing AMPK/ULK1‐mediated autophagy

Abstract Background Diabetes and obesity are associated with muscle atrophy that reduces life quality and lacks effective treatment. Mesenchymal stromal cell (MSC)‐based therapy can ameliorate high fat‐diet (HFD) and immobilization (IM)‐induced muscle atrophy in mice. However, the effect of MSCs on...

Full description

Bibliographic Details
Main Authors: Jia Song, Jidong Liu, Chen Cui, Huiqing Hu, Nan Zang, Mengmeng Yang, Jingwen Yang, Ying Zou, Jinquan Li, Lingshu Wang, Qin He, Xinghong Guo, Ruxing Zhao, Fei Yan, Fuqiang Liu, Xinguo Hou, Zheng Sun, Li Chen
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Muscle atrophy
hucMSCs
Exosome
AMPK/ULK1
Autophagy
Online Access:https://doi.org/10.1002/jcsm.13177

Internet

https://doi.org/10.1002/jcsm.13177

Similar Items