Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants

Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants

Abstract Background Genome-wide association studies (GWASs) have identified multiple risk loci for bipolar disorder (BD). However, pinpointing functional (or causal) variants in the reported risk loci and elucidating their regulatory mechanisms remain challenging. Methods We first integrated chromat...

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Bibliographic Details
Main Authors: Rui Chen, Zhihui Yang, Jiewei Liu, Xin Cai, Yongxia Huo, Zhijun Zhang, Ming Li, Hong Chang, Xiong-Jian Luo
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Genome Medicine
Subjects:
Bipolar disorder
Genome-wide association study (GWAS)
Functional genomics
Transcription factor–disrupting SNPs
Expression quantitative trait loci (eQTL)
Regulatory mechanisms
Online Access:https://doi.org/10.1186/s13073-022-01057-3

Internet

https://doi.org/10.1186/s13073-022-01057-3

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