YY2/PHGDH axis suppresses tumorigenesis by inhibiting tumor cell de novo serine biosynthesis

YY2/PHGDH axis suppresses tumorigenesis by inhibiting tumor cell de novo serine biosynthesis

Metabolic reprogramming is one of the key features of tumors facilitating their rapid proliferation and adaptation to harsh microenvironments. Yin Yang 2 (YY2) has recently been reported as a tumor suppressor downregulated in various types of tumors; however, the molecular mechanisms underlying its...

Full description

Bibliographic Details
Main Authors: Juan Li, Xinxin Luo, Mankun Wei, Zhuolin Li, Yanjun Li, Hezhao Zhao, Makoto Miyagishi, Vivi Kasim, Shourong Wu
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Metabolic reprogramming
Amino acids metabolism
Serine biosynthesis
YY2
PHGDH
Tumorigenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223007965

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223007965

Similar Items