hnRNP K coordinates transcriptional silencing by SETDB1 in embryonic stem cells.

hnRNP K coordinates transcriptional silencing by SETDB1 in embryonic stem cells.

Retrotransposition of endogenous retroviruses (ERVs) poses a substantial threat to genome stability. Transcriptional silencing of a subset of these parasitic elements in early mouse embryonic and germ cell development is dependent upon the lysine methyltransferase SETDB1, which deposits H3K9 trimeth...

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Bibliographic Details
Main Authors: Peter J Thompson, Vered Dulberg, Kyung-Mee Moon, Leonard J Foster, Carol Chen, Mohammad M Karimi, Matthew C Lorincz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4303303?pdf=render

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http://europepmc.org/articles/PMC4303303?pdf=render

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