Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/Nrf2 signaling pathway

Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/Nrf2 signaling pathway

Neonatal hypoxic-ischemic encephalopathy (HIE) is considered a major cause of death and long-term neurological injury in newborns. Studies have demonstrated that oxidative stress and apoptosis play a major role in the progression of neonatal HIE. Echinocystic acid (EA), a natural plant extract, show...

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Bibliographic Details
Main Authors: Yuan Li, Ling Chen, Da Zheng, Jian-Xia Liu, Chao Liu, Shao-Hua Qi, Peng-Chao Hu, Xiao-Fei Yang, Jia-Wei Min
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
echinocystic acid
HIBD
OGD/R
neonatal
oxidative stress
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1103265/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1103265/full

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